Trang 4

Daniel G. TENEN

Professor Tenen is a leader in gen regulation in both normal differentiation và cancer, with a focus on leukemia, lung cancer, and liver cancer. Current efforts include basic studies understanding gen regulation in normal và leukemic hematopoietic stem cells, with an alặng khổng lồ develop novel ways of manipulating ren expression in stem cells as well as exploiting differences between normal & leukemic stem cells as a basis for targeted leukemia stem cell therapy, and the role of stem cell oncofetal proteins in leukemia and solid tumors, especially liver cancer.

Bạn đang xem: Trang 4

daniel.tenencapdoihoanhao.vn.edu.sg


Biosketch
Lab Members
Publications
Biosketch
Affliations

Programme Leader và Senior Principal Investigator, Cancer Science Institute of Singapore, capdoihoanhao.vnDistinguished Professor in Medicine, capdoihoanhao.vn


Education
Year(s)Degree (if applicable)Institute
1971B.A.University of California, Los Angeles CA
1975M.D.Harvard Medical School, Boston MA

Professional Experience
2008 – PresentDirector, Cancer Science Institute of Singapore, National University of Singapore
2008 – PresentProgramme Leader & Senior Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore
2008 – PresentDistinguished Professor in Medicine, National University of Singapore
2005 – PresentDirector, Blood Program, Harvard Stem Cell Institute, Harvard Medical School
1999 – PresentProfessor of Medicine, Harvard Medical School
1994 – 1999Associate Professor of Medicine, Harvard Medical School
1986 – 1993Assistant Professor of Medicine, Harvard Medical School
1978 – 1986Instructor in Medicine, Harvard Medical School
1975 – 1984Research Fellow in Medicine, Harvard Medical School & Dana-Farber Cancer Institute (Laboratory of David M. Livingston)

Lab Members
*

LIU Bee Hui


Senior Research Scientist

Small molecule screening to lớn target SALL4-NuRD interaction.


*

Junsu KWON


Research Fellow

Identification và characterization of novel ncRNA involved in SALL4 regulation in HCC.


*

LIU Yan Jing


Retìm kiếm Fellow

RNA approach for gene specific demethylation


*

Giorgia MARONI


Research Fellow

Lung Cancer research và discovery of novel therapeutic targets in the context of Non Small Cell Lung Cancer (NSCLC)


*

ZHOU Qiling


Research Fellow

Transcriptional regulation of myeloid transcription factors.


TANG Jing Ping


Senior Laboratory Executive

Lab management and work on crystallography và SALL4 drug screening project.


CAO Xinang


PhD Student

PRC2-RNA interaction


Kalpana KUMARI


Research Fellow

RNA specific regulation of DNMT1.


Mishra SRISHTI


PhD Student

Focuses on characterization of novel long non-coding RNA(s) in acute myeloid leukemia


Jeremiah SURYATENGGARH


PhD Student

SALL4-induced Carcinogenesis


Le Kim Anh VU


PhD Student

Bioinformatics study of the regulation of DNA methylation and gene expression mediated by DNMT1-ncRNA interactions. Bioinformatics study of non-coding RNA interaction networks.


Guo Mingrui


PhD Student

Study DNMT3A RNA binding profile and isoforms specific function in AML.

Xem thêm: Thế Nào Là Tự Hoàn Thiện Bản Thân, Vì Sao Phải Tự Hoàn Thiện Bản Thân


Selected Publications

1. Ye M, Zhang H, Yang H, Kobịt R, Staber PB, Cusan M, Levantini E, Welner RS, Bach CS, Zhang J, Krivtsov A, Armstrong SA, Tenen DG. Hematopoietic differentiation is required for initiation of adễ thương myeloid leukemia. 2015. Cell Stem Cell 17:611-623.

2. Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LF, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. năm ngoái. Cancer Cell 27:671-681.

3. Amabile G*, Di Ruscio A*, Müller F*, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG. Dissecting the role of aberrant DNA methylation in human leukemia. năm ngoái. Nat Commun. 6:709. *co-first authors.

4. Staber PB, Zhang Phường., Ye M, Welner RS, Levantini E, Di Ruscio, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel, Yang H, Huang G, Tenen DG. The Runx-PU.1 pathway preserves normal và AML/ETO9a leukemic stem cells. năm trước. Blood 124:2391-2399. PMCID PMC4192750.

5. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figureido Pontes LL, Alberich-Jordomain authority M, Zhang P, Wu M, D’Alò F, Melniông chồng A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. DNMT1-interacting RNAs blochồng gen specific DNA methylation. 2013. Nature 503:371-376. PubMed Central PMCID: PMC3870304.

6. Yong KJ, Gao C, Lim JSJ, Yan B, Yang H, Dimitrov T, Kawasaki A, Ong CW, Wong KF, Lee S, Ravikumar S, Srivastava S, Tian X, Poon RT, Fan ST, Luk JM, Dan YY, Salto-Tellez M, Cnhì L, Tenen DG. Oncofetal Gene SALL4 Defines an Aggressive sầu Hepatocellular Carcinoma Subtype. 2013. N Engl J Med 368:2266-76. PMCID: PMC3781214.

7. Ye M, Zhang H, Amabile G, Yang H, Staber PB, Zhang P, Levantini E, Alberich-Jordà M, Zhang J, Kawasaki A, Tenen DG. C/EBPa controls acquisition và maintenance of adult hematopoietic stem cell quiescence. 2013. Nature Cell Biol. 15:385-94. PMCID: PMC3781213.

8. Staber PB, Zhang Phường., Ye M, Welner R, Nombela-Arrieta C, Bach C; Kerenyi M, Bartholdy BA, Zhang H; Alberich-Jorda M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Gottgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 Levels Balance Cell Cycle Regulators to lớn Prsự kiện Exhaustion of Adult Hematopoietic Stem Cells. 2013. Molecular Cell 49:934-46.

Xem thêm: Hình Ảnh Về Mẹ Và Con Đẹp Xúc Động Và Thiêng Liêng Nhất, Sheet Nhạc: Mẹ Yêu

9. Amabile G, Welner RS, Nombela-Arrieta C, D’Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In Vivo Generation of Transplantable Human Hematopoietic Cells from Induced Pluripotent Stem Cells. 2013. Blood 121:1255-64.

10. Pabst T, Mueller BU, Zhang Phường, Radomska HS, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen DG. Dominant-negative sầu mutations of CEBPA, encoding CCAAT/Enhancer Binding Protein-? (C/EBP?) in axinh tươi myeloid leukemia. 2001: Nature Genetics 27:263-270


Chuyên mục: Kiến thức