Kantai Collection

Catalog No. Product Name Information sản phẩm Use Citations sản phẩm Validations
S2457 Clindamycin HCl

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

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Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413
S5228 Minoxidil sulphate

Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.

S8808 DC661

DC661 is capable of deacidifying the lysosome và inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis.

J Neurochem, 2022, 10.1111/jnc.15606 FEBS J, 2022, 10.1111/febs.16447 Biomed Pharmacother, 2022, 145:112432
S3458 WAY-169916

WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER) that acts by inhibiting NF-kB transcriptional activity.

E0212 Cornuside

Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. Et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons.

E0980 Saikosaponin B1

Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting Smoothened (SMO).

P1129 Substance phường

Substance p. (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance p. Is neurokinin 1 receptor (NK1-receptor, NK1R).

E2437 Denudatine

Denudatine is primarily isolated from plants of the genera Aconitum và Delphinium. Denudatine has effects on the action potential of ventricular fibers & inhibits the arrhythmogenic action of aconitine.

E0524 Spinosad

Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader kích hoạt spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.

S1271 Acarbose

Acarbose(BAY g 5421) is an inhibitor of intestinal alpha-glucosidase, used khổng lồ treat type 2 diabetes mellitus.

Infect Genet Evol, 2020, 81:104210
S2458 Clonidine HCl

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

Mol Pain, 2022, 18:17448069221107810
S8057 Pacritinib (SB1518)

Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) & Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.

Clin Transl Med, 2022, 12(6):e894 J Innate Immun, 2022, 1-11 Sci Rep, 2022, 12(1):7
S3940 3"-Hydroxypterostilbene

3"-Hydroxypterostilbene (3"-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3"-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, & 70.9 µM for COLO 205, HCT-116, & HT-29 cells, respectively) by inducing apoptosis and autophagy. 3"-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, và p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

S5459 Aucubin

Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to lớn show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.

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S9189 Oroxin A

Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ và inhibits α-glucosidase, exerting antioxidant activity.

S5739 Nebivolol

Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension & also for left ventricular failure.

Front Pharmacol, 2021, 12:691998 Sci Rep, 2015, 5:16406
S3459 Creatine riboside

Creatine riboside, a urinary metabolite, is a diagnostic & prognostic biomarker of lung cancer.

E0213 Bruceine D

Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.

E0525 Colistin

Colistin, a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane.

S1653 Tretinoin (NSC 122758)

Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) và the retinoid X receptor (RXR), can induce granulocytic differentiation và apoptosis in acute promyelocytic leukemia (APL) cells.

S2459 Clozapine

Clozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.

Anticancer Res, 2021, 41(2):687-697 Ann Neurol, 2020, 10.1002/ana.25935 BMC Evol Biol, 2018, 18(1):89
S3199 Reboxetine mesylate

Reboxetine (PNU 155950E) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.

Cancer Discov, 2020, CD-20-0160 Micromachines (Basel), 2018, 9(6)E274
S5224 Adrafinil

Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used khổng lồ relieve excessive sleepiness và inattention in elderly patients.

S9190 Oroxin B

Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER bức xúc in malignant lymphoma cells và has antioxidant activity. Oroxin B significantly inhibits proliferation và induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, và p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.

Theranostics, 2022, 12(2):910-928 J Cancer, 2021, 12(7):2140-2150
S6235 Sodium dehydroacetate

Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide & bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics và personal care products in order khổng lồ extend the shelf-life by preventing microbial contamination.

S8832 Branebrutinib (BMS-986195)

Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.