KANTAI COLLECTION
| S2457 | Clindamycin HCl | Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. Bạn đang xem: Kantai collection | Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413 | |
| S5228 | Minoxidil sulphate | Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure. | ||
| S8808 | DC661 | DC661 is capable of deacidifying the lysosome và inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis. | J Neurochem, 2022, 10.1111/jnc.15606 FEBS J, 2022, 10.1111/febs.16447 Biomed Pharmacother, 2022, 145:112432 | |
| S3458 | WAY-169916 | WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER) that acts by inhibiting NF-kB transcriptional activity. | ||
| E0212 | Cornuside | Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. Et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons. | ||
| E0980 | Saikosaponin B1 | Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting Smoothened (SMO). | ||
| P1129 | Substance phường | Substance p. (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance p. Is neurokinin 1 receptor (NK1-receptor, NK1R). | ||
| E2437 | Denudatine | Denudatine is primarily isolated from plants of the genera Aconitum và Delphinium. Denudatine has effects on the action potential of ventricular fibers & inhibits the arrhythmogenic action of aconitine. | ||
| E0524 | Spinosad | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader kích hoạt spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. | ||
| S1271 | Acarbose | Acarbose(BAY g 5421) is an inhibitor of intestinal alpha-glucosidase, used khổng lồ treat type 2 diabetes mellitus. | Infect Genet Evol, 2020, 81:104210 | |
| S2458 | Clonidine HCl | Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. | Mol Pain, 2022, 18:17448069221107810 | |
| S8057 | Pacritinib (SB1518) | Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) & Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3. | Clin Transl Med, 2022, 12(6):e894 J Innate Immun, 2022, 1-11 Sci Rep, 2022, 12(1):7 | |
| S3940 | 3"-Hydroxypterostilbene | 3"-Hydroxypterostilbene (3"-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3"-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, & 70.9 µM for COLO 205, HCT-116, & HT-29 cells, respectively) by inducing apoptosis and autophagy. 3"-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, và p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. | ||
| S5459 | Aucubin | Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to lớn show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages. Xem thêm: Hướng Dẫn Tải Game Warcraft 3 Cho Pc, Cách Tải Game Warcraft 3 | ||
| S9189 | Oroxin A | Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ và inhibits α-glucosidase, exerting antioxidant activity. | ||
| S5739 | Nebivolol | Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension & also for left ventricular failure. | Front Pharmacol, 2021, 12:691998 Sci Rep, 2015, 5:16406 | |
| S3459 | Creatine riboside | Creatine riboside, a urinary metabolite, is a diagnostic & prognostic biomarker of lung cancer. | ||
| E0213 | Bruceine D | Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. | ||
| E0525 | Colistin | Colistin, a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane. | ||
| S1653 | Tretinoin (NSC 122758) | Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) và the retinoid X receptor (RXR), can induce granulocytic differentiation và apoptosis in acute promyelocytic leukemia (APL) cells. | ||
| S2459 | Clozapine | Clozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia. | Anticancer Res, 2021, 41(2):687-697 Ann Neurol, 2020, 10.1002/ana.25935 BMC Evol Biol, 2018, 18(1):89 |  |
| S3199 | Reboxetine mesylate | Reboxetine (PNU 155950E) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM. | Cancer Discov, 2020, CD-20-0160 Micromachines (Basel), 2018, 9(6)E274 | |
| S5224 | Adrafinil | Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used khổng lồ relieve excessive sleepiness và inattention in elderly patients. | ||
| S9190 | Oroxin B | Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER bức xúc in malignant lymphoma cells và has antioxidant activity. Oroxin B significantly inhibits proliferation và induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, và p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment. | Theranostics, 2022, 12(2):910-928 J Cancer, 2021, 12(7):2140-2150 | |
| S6235 | Sodium dehydroacetate | Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide & bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics và personal care products in order khổng lồ extend the shelf-life by preventing microbial contamination. | ||
| S8832 | Branebrutinib (BMS-986195) | Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
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